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| Lesion Grading or Semi-Quantitative Histopathology
There
are two types of pathology data in nonclinical toxicology
studies. These include qualitative variables or nonnumeric variables that can't be measured and
quantitative variables or numerical variables that can be
measured. Examples of qualitative variables include gender,
animal species/strain, and supplier. Examples of
quantitative variables include most clinical pathology
parameters (i.e. hematology and clinical chemistry values),
and body and organ weights. Note that quantitative variables
are either discrete (which can assume only certain values,
and there are usually "gaps" between the values, such as the
specific grading of histopathological lesions) or continuous
(which can assume any value within a specific range, such as
animal age, body weight, or bilirubin value.)
Walker Downey & Associates, Inc. has extensive experience in the analysis of semi-quantitative histopathological scoring of tissue lesions. Oftentimes our contemporary approach will employ evaluations “with and without sexes combined”, and interval data when available. Where necessary we can apply transformations to normalize the data and increase the power of the analysis to the point where parametric tests are applicable. Please contact us at info@walkerdowney.com to discuss how we may help to improve your semi-quantitative analyses. Case Studies
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